Liste de mes publications


411: Herve J, Sa Cunha A, Liu B, Valogne Y, Longuet M, Boisgard R, Bregerie O, Roux J, Guettier C, Cales C, Tavitian B, Samuel D, Clerc C, Brechot C and Faivre J.

Internal radiotherapy of liver cancer with rat Hepatocarcinoma-Intestine-Pancreas gene as a liver tumor-specific promoter.

2007. Submitted.

410: Sobesky R, Feray C, Rimlinger F, Derian N, Dos Santos A, Roque-Afonso A-M, Samuel D, Bréchot C and Thiers V.

Distinct Hepatitis C Virus Core and F protein quasispecies in tumoral and nontumoral hepatocytes.

Hepatology 2007. In press.

409: Dos Santos A, Thiers V, Sar S, Derian N, Bensalem N, Yilmaz F, Bralet M.P, Ducot B, Brechot C and Demaugre F.

Contribution of laser microdissection-based technology to proteomic analysis in hepatocellular carcinoma developing on cirrhosis.

Proteomics. 2007;6: 545-554

408: Liu B, Herve J, Bioulac-Sage P, Valogne Y, Roux J, Yilmaz F, Boisgard R, Guettier C, Cales P, Tavitian B, Samuel D, Clerc J, Brechot C, Faivre J.

Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma.

Gastroenterology. 2007 Apr;132(4):1495-503. Epub 2007 Jan 26.

407: Yan XB, Battaglia S, Boucreux D, Chen Z, Brechot C, Pavio N.

Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR.

Virus Res. 2007 Apr;125(1):79-87. Epub 2007 Jan 30.

406: Robert A, Margall-Ducos G, Guidotti JE, Bregerie O, Celati C, Brechot C, Desdouets C.

The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells.

J Cell Sci. 2007 Feb 15;120(Pt 4):628-37. Epub 2007 Jan 30. Erratum in: J Cell Sci. 2007 Mar 1;120(Pt 5):918.

405: Chami M, Benali NL, Brechot C, Paterlini-Brechot P.

[Impact of calcium signaling in liver carcinogenesis]

Med Sci (Paris). 2007 Feb;23(2):133-5. French.




404: Lieu HT, Simon MT, Nguyen-Khoa T, Kebede M, Cortes A, Tebar L, Smith AJ, Bayne R, Hunt SP, Brechot C, Christa L.         

Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.

Hepatology. 2006 Dec;44(6):1452-64.

403: Hervieu V, Christa L, Gouysse G, Bouvier R, Chayvialle JA, Brechot C, Scoazec JY.

HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors.

Hum Pathol. 2006 Aug;37(8):1066-75. Epub 2006 Jun 16.

402: Toyoda H, Kumada T, Bregerie O, Brechot C, Desdouets C.

Conserved balance of hepatocyte nuclear DNA content in mononuclear and binuclear hepatocyte populations during the course of chronic viral hepatitis.

World J Gastroenterol. 2006 Jul 28;12(28):4546-8.

401: Kremsdorf D, Soussan P, Paterlini-Brechot P, Brechot C.

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis.

Oncogene. 2006 Jun 26;25(27):3823-33. Review.

400: Chignard N, Shang S, Wang H, Marrero J, Brechot C, Hanash S, Beretta L.  

Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera.

Gastroenterology. 2006 Jun;130(7):2010-22.

399: Mancini-Bourgine M, Fontaine H, Brechot C, Pol S, Michel ML.

Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV


Vaccine. 2006 May 22;24(21):4482-9. Epub 2005 Aug 18.

398: Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Van Rooijen N,

Battaglia S, Blanc C, Eling W, Sauerwein R, Hannoun L, Belghiti J, Brechot C,

Kremsdorf D, Druilhe P.

Liver-stage development of Plasmodium falciparum, in a humanized mouse model.

J Infect Dis. 2006 Apr 1;193(7):996-1004.


397: Peltekian C, Gordien E, Garreau F, Meas-Yedid V, Soussan P, Willams V, Chaix ML, Olivo-Marin JC, Brechot C, Kremsdorf D.

Human MxA protein participates to the interferon-related inhibition of

hepatitis B virus replication in female transgenic mice.

J Hepatol. 2005 Dec;43(6):965-72. Epub 2005 Jul 14.

396: Haeffner-Cavaillon N, Graillot-Gak C, Brechot C.

Automated grading of research performance clearly fails to measure up.

Nature. 2005 Dec 1;438(7068):559.

395: Pavio N, Battaglia S, Boucreux D, Arnulf B, Sobesky R, Hermine O, Brechot C.

Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway.

Oncogene. 2005 Sep 8;24(40):6119-32.

394: Lieu HT, Batteux F, Simon MT, Cortes A, Nicco C, Zavala F, Pauloin A,

Tralhao JG, Soubrane O, Weill B, Brechot C, Christa L.

HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice.

Hepatology. 2005 Sep;42(3):618-26.

393: Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Brechot C,

Paterlini-Brechot P.

Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas.

Gut. 2005 Aug;54(8):1162-8.

392: Toyoda H, Bregerie O, Vallet A, Nalpas B, Pivert G, Brechot C, Desdouets C.

Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis.

Gut. 2005 Feb;54(2):297-302.

391: Andre P, Perlemuter G, Budkowska A, Brechot C, Lotteau V.

Hepatitis C virus particles and lipoprotein metabolism.

Semin Liver Dis. 2005 Feb;25(1):93-104. Review.


390: Faivre J, Clerc J, Gerolami R, Herve J, Longuet M, Liu B, Roux J, Moal F, Perricaudet M, Brechot C.

Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats.

Cancer Res. 2004 Nov 1;64(21):8045-51. Erratum in: Cancer Res. 2004 Dec


389: Brechot C.

Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms.

Gastroenterology. 2004 Nov;127(5 Suppl 1):S56-61. Review.

388: Demaugre F, Philippe Y, Sar S, Pileire B, Christa L, Lasserre C, Brechot C.

HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling.

Eur J Biochem. 2004 Oct;271(19):3812-20.

387: Mancini-Bourgine M, Fontaine H, Scott-Algara D, Pol S, Brechot C, Michel ML.

Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers.

Hepatology. 2004 Oct; 40(4):874-82.

386: Brechot C.

[Health translational research, a new paradigm]

Med Sci (Paris). 2004 Oct;20(10):939-40. French. No abstract available.

385: Girard S, Vossman E, Misek DE, Podevin P, Hanash S, Brechot C, Beretta L.

Hepatitis C virus NS5A-regulated gene expression and signaling revealed via

microarray and comparative promoter analyses.

Hepatology. 2004 Sep;40(3):708-18.

384: Vona G, Tuveri R, Delpuech O, Vallet A, Canioni D, Ballardini G, Baptiste Trabut J, Le Bail B, Nalpas B, Carnot F, Pol S, Brechot C, Thiers V.

Intrahepatic hepatitis C virus RNA quantification in microdissected


J Hepatol. 2004 Apr;40(4):682-8.

383: Vona G, Estepa L, Beroud C, Damotte D, Capron F, Nalpas B, Mineur A, Franco

D, Lacour B, Pol S, Brechot C, Paterlini-Brechot P.

Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer.

Hepatology. 2004 Mar;39(3):792-7.

382: Lebray P, Zylberberg H, Hue S, Poulet B, Carnot F, Martin S, Chretien Y, Pol S, Caillat-Zuckman S, Brechot C, Nalpas B.

Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C.

J Viral Hepat. 2004 Mar;11(2):175-82.

381: Gerolami R, Uch R, Faivre J, Garcia S, Hardwigsen J, Cardoso J, Mathieu S,Bagnis C, Brechot C, Mannoni P.

Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors.

J Hepatol. 2004 Feb;40(2):291-7.

380: Pol S, Carnot F, Nalpas B, Lagneau JL, Fontaine H, Serpaggi J, Serfaty L, Bedossa P, Brechot C.

Reversibility of hepatitis C virus-related cirrhosis.

Hum Pathol. 2004 Jan;35(1):107-12.


379: Perlemuter G, Letteron P, Carnot F, Zavala F, Pessayre D, Nalpas B, Brechot C.

Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model.

J Hepatol. 2003 Dec;39(6):1020-7.

378: Gerolami R, Uch R, Brechot C, Mannoni P, Bagnis C.

Gene therapy of hepatocarcinoma: a long way from the concept to the therapeutical impact.

Cancer Gene Ther. 2003 Sep;10(9):649-60. Review

377: Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, Carnot F, Tralhao JG, Brechot C, Christa L.

HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway.

FASEB J. 2003 Aug;17(11):1441-50.

376: Iavarone M, Trabut JB, Delpuech O, Carnot F, Colombo M, Kremsdorf D, Brechot C, Thiers V.

Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection.

J Hepatol. 2003 Aug;39(2):253-61.

375: Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C.

Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

Oncogene. 2003 Jun 19;22(25):3911-6.

374: Guidotti JE, Bregerie O, Robert A, Debey P, Brechot C, Desdouets C.

Liver cell polyploidization: a pivotal role for binuclear hepatocytes.

J Biol Chem. 2003 May 23;278(21):19095-101. Epub 2003 Mar 7.

373: Brechot C.

New research actions and organizations in France.

Hepatology. 2003 May;37(5):970-1. Review.

372: Soussan P, Tuveri R, Nalpas B, Garreau F, Zavala F, Masson A, Pol S, Brechot C, Kremsdorf D.

The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis.

J Hepatol. 2003 Mar;38(3):343-8.

371: Lamas E, Chassoux D, Decaux JF, Brechot C, Debey P.

Quantitative fluorescence imaging approach for the study of polyploidization in hepatocytes.

J Histochem Cytochem. 2003 Mar;51(3):319-30.

370: Gozuacik D, Chami M, Lagorce D, Faivre J, Murakami Y, Poch O, Biermann E, Knippers R, Brechot C, Paterlini-Brechot P.

Identification and functional characterization of a new member of the human Mcm protein family: hMcm8.

Nucleic Acids Res. 2003 Jan 15;31(2):570-9.

369: Giannini C, Brechot C.

Hepatitis C virus biology.

Cell Death Differ. 2003 Jan;10 Suppl 1:S27-38. Review.

368: Lebray P, Vallet-Pichard A, Michel ML, Fontaine H, Sobesky R, Brechot C, Pol S.

Immunomodulatory drugs and therapeutic vaccine in chronic hepatitis B infection.

J Hepatol. 2003;39 Suppl 1:S151-9. Review. No abstract available


367: Wang XW, Hussain SP, Huo TI, Wu CG, Forgues M, Hofseth LJ, Brechot C,

Harris CC.

Molecular pathogenesis of human hepatocellular carcinoma.

Toxicology. 2002 Dec 27;181-182:43-7. Review.

366: Lafarge-Frayssinet C, Martin C, Van Binh PN, Achard-Ellouk S, Duc HT, Frayssinet C, Cardoso G, Desauty G, Warnet JM, Brechot C, Sarasin A.

Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma.

Anticancer Res. 2002 Nov-Dec;22(6C):3895-904.

365: Sa Cunha A, Bonte E, Dubois S, Chretien Y, Eraiser T, Degott C, Brechot C, Tran PL.

Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.

J Hepatol. 2002 Aug;37(2):222-30.

364: Hermine O, Lefrere F, Bronowicki JP, Mariette X, Jondeau K, Eclache-Saudreau V, Delmas B, Valensi F, Cacoub P, Brechot C, Varet B, Troussard X.

Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection.

N Engl J Med. 2002 Jul 11;347(2):89-94.

363: Brechot C.

INSERM fosters researches on infectious diseases.

Infect Genet Evol. 2002 Jul;1(4):311-2.

362: Bichr S, Rende-Fournier R, Vona G, Yamamoto AM, Depla E, Maertens G, Brechot C.

Detection of neutralizing antibodies to hepatitis C virus using a biliary cell infection model.

J Gen Virol. 2002 Jul;83(Pt 7):1673-8.

361: Giannini C, Caini P, Giannelli F, Fontana F, Kremsdorf D, Brechot C, Zignego AL.

Hepatitis C virus core protein expression in human B-cell lines does not significantly modify main proliferative and apoptosis pathways.

J Gen Virol. 2002 Jul;83(Pt 7):1665-71.

360: Andre P, Komurian-Pradel F, Deforges S, Perret M, Berland JL, Sodoyer M, Pol S, Brechot C, Paranhos-Baccala G, Lotteau V.

Characterization of low- and very-low-density hepatitis C virus RNA-containing particles.

J Virol. 2002 Jul;76(14):6919-28.

359: Tralhao JG, Roudier J, Morosan S, Giannini C, Tu H, Goulenok C, Carnot F, Zavala F, Joulin V, Kremsdorf D, Brechot C.

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6991-6.

358: Delpuech O, Trabut JB, Carnot F, Feuillard J, Brechot C, Kremsdorf D.

 Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma.

Oncogene. 2002 Apr 25;21(18):2926-37.

357: Girard S, Shalhoub P, Lescure P, Sabile A, Misek DE, Hanash S, Brechot C, Beretta L.

An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis.

Virology. 2002 Apr 10;295(2):272-83.

356: Le Naour F, Brichory F, Misek DE, Brechot C, Hanash SM, Beretta L.

A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis.

Mol Cell Proteomics. 2002 Mar;1(3):197-203.

355: Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Jessus C, Brechot C, Sobczak-Thepot J.

Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2.

Oncogene. 2002 Feb 28;21(10):1493-500.

354: Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chretien Y, Koike K, Pessayre D, Chapman J, Barba G, Brechot C.

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis.

FASEB J. 2002 Feb;16(2):185-94.

353: Zylberberg H, Nalpas B, Carnot F, Skhiri H, Fontaine H, Legendre C, Kreis H, Brechot C, Pol S.

Severe evolution of chronic hepatitis C in renal transplantation: a case control study.

Nephrol Dial Transplant. 2002 Jan;17(1):129-33.


352: Tu H, Bonura C, Giannini C, Mouly H, Soussan P, Kew M, Paterlini-Brechot P, Brechot C, Kremsdorf D.

Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues.

Cancer Res. 2001 Nov 1;61(21):7803-10.

351: Desenclos JC, Bourdiol-Razes M, Rolin B, Garandeau P, Ducos J, Brechot C, Thiers V.

Hepatitis C in a ward for cystic fibrosis and diabetic patients: possible transmission by spring-loaded finger-stick devices for self-monitoring of capillary blood glucose.

Infect Control Hosp Epidemiol. 2001 Nov;22(11):701-7.

350: Op De Beeck A, Sobczak-Thepot J, Sirma H, Bourgain F, Brechot C, Caillet-Fauquet P.

NS1- and minute virus of mice-induced cell cycle arrest: involvement of p53 and p21(cip1).

J Virol. 2001 Nov;75(22):11071-8.

349: Bottazzi ME, Buzzai M, Zhu X, Desdouets C, Brechot C, Assoian RK.

Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.

Mol Cell Biol. 2001 Nov;21(22):7607-16.

348: Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Brechot C, Sobczak-Thepot J, Jessus C.

Membrane-anchored cyclin A2 triggers Cdc2 activation in Xenopus oocyte.

FEBS Lett. 2001 Oct 12;506(3):243-8.

347: Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot P.

 Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging.

Oncogene. 2001 Sep 27;20(43):6233-40.

346: Delhem N, Sabile A, Gajardo R, Podevin P, Abadie A, Blaton MA, Kremsdorf D, Beretta L, Brechot C.

Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein.

Oncogene. 2001 Sep 13;20(41):5836-45.

345: Fontaine H, Nalpas B, Poulet B, Carnot F, Zylberberg H, Brechot C, Pol S.

Hepatitis activity index is a key factor in determining the natural history of chronic hepatitis C.

Hum Pathol. 2001 Sep;32(9):904-9.

344: Nalpas B, Martin S, Fontaine H, Fabbro-Peray P, Brechot C, Pol S.

Impact of medical recommendations on alcohol consumption in HCV positive patients.

J Hepatol. 2001 Aug;35(2):312-3. No abstract available.

343: Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Brechot P.

Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely “occult”?

Hepatology. 2001 Jul;34(1):194-203. Review. No abstract available.

342: Huo TI, Wang XW, Forgues M, Wu CG, Spillare EA, Giannini C, Brechot C, Harris CC.

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.

Oncogene. 2001 Jun 21;20(28):3620-8.

341: Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P.

SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.

J Cell Biol. 2001 Jun 11;153(6):1301-14.

340: Podevin P, Sabile A, Gajardo R, Delhem N, Abadie A, Lozach PY, Beretta L, Brechot C.

Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner.

Hepatology. 2001 Jun;33(6):1503-11.

339: Gerolami R, Uch R, Cardoso J, Bagnis C, Mannoni P, Brechot C.

[Gene therapy for hepatocellular carcinoma. From the idea to clinical trials]

Gastroenterol Clin Biol. 2001 Mar;25(3):273-86. Review. French.

338: Michel ML, Pol S, Brechot C, Tiollais P.

Immunotherapy of chronic hepatitis B by anti HBV vaccine: from present to future.

Vaccine. 2001 Mar 21;19(17-19):2395-9. Review.

337: Gerolami R, Uch R, Cardoso J, Bagnis C, Mannoni P, Brechot C.

[Gene therapy for hepatocellular carcinoma. From the idea to clinical trials]

Gastroenterol Clin Biol. 2001 Mar;25(3):273-86. Review. French.

336: Gordien E, Rosmorduc O, Peltekian C, Garreau F, Brechot C, Kremsdorf D.

Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein.

J Virol. 2001 Mar;75(6):2684-91.

335: Soussan P, Pol S, Garreau F, Brechot C, Kremsdorf D.

Vaccination of chronic hepatitis B virus carriers with preS2/S envelope protein

is not associated with the emergence of envelope escape mutants.

J Gen Virol. 2001 Feb;82(Pt 2):367-71.


334: Cavalloni G, Dane A, Piacibello W, Bruno S, Lamas E, Brechot C, Aglietta M.

The involvement of human-nuc gene in polyploidization of K562 cell line.

Exp Hematol. 2000 Dec;28(12):1432-40.

333: Zylberberg H, Benhamou Y, Lagneaux JL, Landau A, Chaix ML, Fontaine H, Bochet M, Poynard T, Katlama C, Pialoux G, Brechot C, Pol S.

Safety and efficacy of interferon-ribavirin combination therapy in HCV-HIV

coinfected subjects: an early report.

Gut. 2000 Nov;47(5):694-7.

332: Fontaine H, Nalpas B, Carnot F, Brechot C, Pol S.

Effect of pregnancy on chronic hepatitis C: a case-control study.

Lancet. 2000 Oct 14;356(9238):1328-9.

331: Zylberberg H, Nalpas B, Pol S, Brechot C, Viard JP.

Is there a relationship between hepatitis C virus infection and antiretroviral-associated lipoatrophy?

AIDS. 2000 Sep 8;14(13):2055. No abstract available.

330: Tuveri R, Perret JL, Delaporte E, Nguemby-Mbina C, D’Allones LR, Henzel D, Faivre D, Scarpa B, Contu P, Colombo M, Thiers V, Brechot C, Larouze B.

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Am J Trop Med Hyg. 2000 Sep-Oct;63(3-4):192-8.

329: Gerolami R, Uch R, Jordier F, Chapel S, Bagnis C, Brechot C, Mannoni P.

Gene transfer to hepatocellular carcinoma: transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors.

Cancer Gene Ther. 2000 Sep;7(9):1286-92.

328: Zylberberg H, Fontaine H, Correas JM, Carnot F, Brechot C, Pol S.

Dilated bile duct in patients receiving narcotic substitution: an early report.

J Clin Gastroenterol. 2000 Sep;31(2):159-61.

327: Winston N, Bourgain-Guglielmetti F, Ciemerych MA, Kubiak JZ, Senamaud-Beaufort C, Carrington M, Brechot C, Sobczak-Thepot J.

Early development of mouse embryos null mutant for the cyclin A2 gene occurs in the absence of maternally derived cyclin A2 gene products.

Dev Biol. 2000 Jul 1;223(1):139-53.

326: Tuveri R, Jaffredo F, Lunel F, Nalpa B, Pol S, Feray C, Marcellin P, Thibault V, Delagneau JF, Opolon P, Scarpa B, Brechot C, Thiers V.

Impact of TT virus infection in acute and chronic, viral- and non viral-related liver diseases.

J Hepatol. 2000 Jul;33(1):121-7.

325: Fontaine H, Chaix ML, Lagneau JL, Brechot C, Pol S.

Recovery from chronic hepatitis C in long-term responders to ribavirin plus interferon alfa.

Lancet. 2000 Jul 1;356(9223):41.

324: Chami M, Gozuacik D, Saigo K, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot P.

Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis.

Oncogene. 2000 Jun 8;19(25):2877-86.

323: Pol S, Nalpas B, Bourliere M, Couzigou P, Tran A, Abergel A, Zarski JP, Berthelot P, Brechot C.

Combination of ribavirin and interferon-alfa surpasses high doses of interferon-alfa alone in patients with genotype-1b-related chronic hepatitis C.

Hepatology. 2000 Jun;31(6):1338-44.

322: Mejean A, Vona G, Nalpas B, Damotte D, Brousse N, Chretien Y, Dufour B, Lacour B, Brechot C, Paterlini-Brechot P.

Detection of circulating prostate derived cells in patients with prostate adenocarcinoma is an independent risk factor for tumor recurrence.

J Urol. 2000 Jun;163(6):2022-9.

321: Paterlini-Brechot P, Vona G, Brechot C.

Circulating tumorous cells in patients with hepatocellular carcinoma. Clinical impact and future directions.

Semin Cancer Biol. 2000 Jun;10(3):241-9. Review.

320: Brechot C, Gozuacik D, Murakami Y, Paterlini-Brechot P.

Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

Semin Cancer Biol. 2000 Jun;10(3):211-31. Review.

319: Brechot C.


Semin Cancer Biol. 2000 Jun;10(3):159.

318: Fontaine H, Thiers V, Chretien Y, Zylberberg H, Poupon RE, Brechot C, Legendre C, Kreis H, Pol S.

HBV genotypic resistance to lamivudine in kidney recipients and hemodialyzed patients.

Transplantation. 2000 May 27;69(10):2090-4.

317: Zylberberg H, Chaix ML, Brechot C.

Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha.

Ann Intern Med. 2000 May 16;132(10):845-6.

316: Bilbao R, Gerolami R, Bralet MP, Qian C, Tran PL, Tennant B, Prieto J, Brechot C.

Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ ganciclovir therapy of hepatocellular carcinoma: the woodchuck animal model.

Cancer Gene Ther. 2000 May;7(5):657-62.

315: Perlemuter G, Sabile A, Brechot C.

[Interactions between hepatitis C virus and hepatic lipid metabolism]

Gastroenterol Clin Biol. 2000 May;24(5):547-53. Review. French.

314: Nalpas B, Zylberberg H, Dubois F, Presles MA, Gillant JC, Lienard M, Delemotte B, Brechot C.

[Prevalence of infection by hepatitis viruses in a rural area. Analysis according to risk factors and alcohol consumption]

Gastroenterol Clin Biol. 2000 May;24(5):536-40. French.

313: Pol S, Michel ML, Brechot C.

Immune therapy of hepatitis B virus (HBV) chronic infection. European experience.

Acta Gastroenterol Belg. 2000 Apr-Jun;63(2):194-6. Review.

312: Desdouets C, Brechot C.

p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.

Pathol Biol (Paris). 2000 Apr;48(3):203-10. Review.

311: Christa L, Pauloin A, Simon MT, Stinnakre MG, Fontaine ML, Delpal S, Ollivier-Bousquet M, Brechot C, Devinoy E.

High expression of the human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein (HIP/PAP) gene in the mammary gland of lactating transgenic mice. Secretion into the milk and purification of the HIP/PAP lectin.

310: Pol S, Samuel D, Cadranel J, Legendre C, Bismuth H, Brechot C, Kreis H.

Hepatitis and solid organ transplantation.

Transplant Proc. 2000 Mar;32(2):454-7. Review.

Eur J Biochem. 2000 Mar;267(6):1665-71.

309: Gerolami R, Cardoso J, Lewin M, Bralet MP, Sa Cunha A, Clement O, Brechot C, Tran PL.

Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes.

Cancer Res. 2000 Feb 15;60(4):993-1001.

308: Hegenbarth S, Gerolami R, Protzer U, Tran PL, Brechot C, Gerken G, Knolle PA.

Liver sinusoidal endothelial cells are not permissive for adenovirus type 5.

Hum Gene Ther. 2000 Feb 10;11(3):481-6.

307: Pol S, Michel ML, Brechot C.

Immune therapy of hepatitis B virus chronic infection.

Hepatology. 2000 Feb;31(2):548-9. No abstract available.

306: Kirk GD, Camus-Randon AM, Mendy M, Goedert JJ, Merle P, Trepo C, Brechot C, Hainaut P, Montesano R.

Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.

J Natl Cancer Inst. 2000 Jan 19;92(2):148-53.

305: Vona G, Sabile A, Louha M, Sitruk V, Romana S, Schutze K, Capron F, Franco D, Pazzagli M, Vekemans M, Lacour B, Brechot C, Paterlini-Brechot P.

Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells.

Am J Pathol. 2000 Jan;156(1):57-63.

304: Soussan P, Garreau F, Zylberberg H, Ferray C, Brechot C, Kremsdorf D.

 In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA.

J Clin Invest. 2000 Jan;105(1):55-60.


303: Christa L, Simon MT, Brezault-Bonnet C, Bonte E, Carnot F, Zylberberg H, Franco D, Capron F, Roskams T, Brechot C.

Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells.

Am J Pathol. 1999 Nov;155(5):1525-33.

302: Bluteau O, Legoix P, Bayer J, Bioulac-Sage P, Flejou JF, Capron F, Monges G, Brechot C, Thomas G, Laurent-Puig P, Zucman-Rossi J.

[Semi-automated quantitative method for detecting the loss of heterozygosity at the long arm of chromosome 4 in hepatocellular carcinoma]

Gastroenterol Clin Biol. 1999 Nov;23(11):1225-32. French.

301: Sabile A, Perlemuter G, Bono F, Kohara K, Demaugre F, Kohara M, Matsuura Y, Miyamura T, Brechot C, Barba G.

Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates.

Hepatology. 1999 Oct;30(4):1064-76.

300: Bonura C, Paterlini-Brechot P, Brechot C.

Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas.

Hepatology. 1999 Sep;30(3):677-81.

299: Poynard T, Daurat V, Chevret S, Moussalli J, Degos F, Bailly F, Borotto E, Buffet C, Bartolomei-Portal I, Richardet JP, Riachi G, Calmus Y, Brechot C, Vidaud M, Olivi M, Bedossa P, Riffaud PC, Chastang C.

A short induction regimen of interferon-alpha is not effective for treatment of relapse in chronic hepatitis C: a randomized trial. For the multicentre GER-CYT-01 group.

J Viral Hepat. 1999 Sep;6(5):381-6.

298: Weil R, Sirma H, Giannini C, Kremsdorf D, Bessia C, Dargemont C, Brechot C, Israel A.

Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.

Mol Cell Biol. 1999 Sep;19(9):6345-54.

297: Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C.

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

Oncogene. 1999 Aug 26;18(34):4848-59.

296: McIntyre M, Desdouets C, Senamaud-Beaufort C, Laurent-Winter C, Lamas E, Brechot C.

Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions.

Oncogene. 1999 Aug 12;18(32):4577-85.

295: Abergel C, Chenivesse S, Stinnakre MG, Guasco S, Brechot C, Claverie JM, Devinoy E, Christa L.

Crystallization and preliminary crystallographic study of HIP/PAP, a human C-lectin overexpressed in primary liver cancers.

Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1487-9.

294: Sabile A, Louha M, Bonte E, Poussin K, Vona G, Mejean A, Chretien Y, Bougas L, Lacour B, Capron F, Roseto A, Brechot C, Paterlini-Brechot P.

Efficiency of Ber-EP4 antibody for isolating circulating epithelial tumor cells before RT-PCR detection.

Am J Clin Pathol. 1999 Aug;112(2):171-8.

293: Zignego AL, Brechot C.

Extrahepatic manifestations of HCV infection: facts and controversies.

J Hepatol. 1999 Aug;31(2):369-76. Review. No abstract available.

292: Desdouets C, Thoresen GH, Senamaud-Beaufort C, Christoffersen T, Brechot C, Sobczak-Thepot J.

CAMP-dependent positive control of cyclin A2 expression during G1/S transition in primary hepatocytes.

Biochem Biophys Res Commun. 1999 Jul 22;261(1):118-22.

291: Zylberberg H, Thiers V, Lagorce D, Squadrito G, Leone F, Berthelot P, Brechot C, Pol S.

Epidemiological and virological analysis of couples infected with hepatitis C virus.

Gut. 1999 Jul;45(1):112-6.

290: Zylberberg H, Pol S, Thiers V, Chaix ML, Lagorce D, Brechot C, Nalpas B, Berthelot P.

Significance of repeatedly normal aminotransferase activities in HCV-infected patients.

J Clin Gastroenterol. 1999 Jul;29(1):71-5.

289: Pol S, Couzigou P, Bourliere M, Abergel A, Combis JM, Larrey D, Tran A, Moussalli J, Poupon R, Berthelot P, Brechot C.

A randomized trial of ribavirin and interferon-alpha vs. interferon-alpha alone in patients with chronic hepatitis C who were non-responders to a previous treatment. Multicenter Study Group under the coordination of the Necker Hospital, Paris, France.

J Hepatol. 1999 Jul;31(1):1-7.

288: Couillin I, Pol S, Mancini M, Driss F, Brechot C, Tiollais P, Michel ML.

Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens.

J Infect Dis. 1999 Jul;180(1):15-26. Erratum in: J Infect Dis 1999 Nov;180(5):1756.

287: Brechot C.

The direct interplay between HCV NS5A protein and interferon transduction signal: from clinical to basic science.

J Hepatol. 1999 Jun;30(6):1152-4. No abstract available.

286: Lasserre C, Colnot C, Brechot C, Poirier F.

HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo.

Am J Pathol. 1999 May;154(5):1601-10.

285: Loriot MA, Bronowicki JP, Lagorce D, Lakehal F, Persico T, Barba G, Mergey M, Vons C, Franco D, Belghiti J, Giacca M, Housset C, Brechot C.

Permissiveness of human biliary epithelial cells to infection by hepatitis C virus.

Hepatology. 1999 May;29(5):1587-95.

284: Rosmorduc O, Sirma H, Soussan P, Gordien E, Lebon P, Horisberger M, Brechot C, Kremsdorf D.

Inhibition of interferon-inducible MxA protein expression by hepatitis B virus capsid protein.

J Gen Virol. 1999 May;80 ( Pt 5):1253-62.

283: Zylberberg H, Fontaine H, Thepot V, Nalpas B, Brechot C, Pol S.

Triggering of acute alcoholic hepatitis by alpha-interferon therapy.

J Hepatol. 1999 Apr;30(4):722-5.

282: Rosmorduc O, Paterlini P, Poupon R, Brechot C.

[Hepatitis virus and hepatocellular carcinoma]

Gastroenterol Clin Biol. 1999 Mar;23(3):363-75. Review. French.

281: Louha M, Nicolet J, Zylberberg H, Sabile A, Vons C, Vona G, Poussin K, Tournebize M, Capron F, Pol S, Franco D, Lacour B, Brechot C, Paterlini-Brechot P.

Liver resection and needle liver biopsy cause hematogenous dissemination of liver cells.

Hepatology. 1999 Mar;29(3):879-82.

280: Poussin K, Dienes H, Sirma H, Urban S, Beaugrand M, Franco D, Schirmacher P, Brechot C, Paterlini Brechot P.

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas.

Int J Cancer. 1999 Feb 9;80(4):497-505.

279: Zylberberg H, Rimaniol AC, Pol S, Masson A, De Groote D, Berthelot P, Bach JF, Brechot C, Zavala F.

Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity.

J Hepatol. 1999 Feb;30(2):185-91.

278: Pol S, Brechot C.

Treatment of chronic hepatitis C.

Acta Gastroenterol Belg. 1999 Jan-Mar;62(1):32-9; discussion 39-40. Review.

277: Pol S, Zylberberg H, Fontaine H, Brechot C.

Treatment of chronic hepatitis C in special groups.

J Hepatol. 1999;31 Suppl 1:205-9. Review.



276: Zylberberg H, Pialoux G, Carnot F, Landau A, Brechot C, Pol S.

Rapidly evolving hepatitis C virus-related cirrhosis in a human immunodeficiency virus-infected patient receiving triple antiretroviral therapy.

Clin Infect Dis. 1998 Nov;27(5):1255-8.

275: Leone F, Zylberberg H, Squadrito G, Le Guen B, Berthelot P, Pol S, Brechot C.

Hepatitis C virus (HCV) hypervariable region 1 complexity does not correlate with severity of liver disease, HCV type, viral load or duration of infection.

J Hepatol. 1998 Nov;29(5):689-94.

274: Lunel F, Frangeul L, Chuteau C, Fretz C, Thiers V, Azar N, Bidet JM, Huraux JM, Brechot C, Valla D, Opolon P.

Transfusion-associated or nosocomial hepatitis G virus infection in patientsundergoing surgery.

Transfusion. 1998 Nov-Dec;38(11-12):1097-103.

273: Venegas M, Thiers V, Velasco M, Munoz G, Brahm J, Alegria S, Brechot C, Lamas E.

[Hepatitis G infection in Chilean patients with hepatitis C virus: a preliminary report]

Rev Med Chil. 1998 Sep;126(9):1133-4. Spanish. No abstract available.

272: Munoz G, Velasco M, Thiers V, Hurtado C, Brahm J, Larrondo-Lillo M, Guglielmetti A, Smok G, Brechot C, Lamas E.

[Prevalence and genotypes of hepatitis C virus in blood donors and in patients with chronic liver disease and hepatocarcinoma in a Chilean population]

Rev Med Chil. 1998 Sep;126(9):1035-42. Spanish.

271: Zylberberg H, Landau A, Carnot F, Driss F, Chaix ML, Brechot C, Kreis H, Legendre C, Pol S.

Impact of co-infection by hepatitis B virus and hepatitis C virus in renal transplantation.

Transplant Proc. 1998 Sep;30(6):2820-2.

270: Payraudeau V, Sarsat JP, Sobczak J, Brechot C, Albaladejo V.

Cyclin A2 and c-myc mRNA expression in ethinyl estradiol induced liver proliferation.

Mol Cell Endocrinol. 1998 Aug 25;143(1-2):107-16.

269: Brechot C.

Molecular mechanisms of hepatitis B and C viruses related to liver carcinogenesis.

Hepatogastroenterology. 1998 Aug;45 Suppl 3:1189-96.

268: Brechot C, Jaffredo F, Lagorce D, Gerken G, Meyer zum Buschenfelde K, Papakonstontinou A, Hadziyannis S, Romeo R, Colombo M, Rodes J, Bruix J, Williams R, Naoumov N.

Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action.

J Hepatol. 1998 Aug;29(2):173-83. Erratum in: J Hepatol 1998 Oct;29(4):686.

267: Gerolami R, Cardoso J, Bralet MP, Cuenod CA, Clement O, Tran PL, Brechot C.

Enhanced in vivo adenovirus-mediated gene transfer to rat hepatocarcinomas by selective administration into the hepatic artery.

Gene Ther. 1998 Jul;5(7):896-904.

266: Bronowicki JP, Loriot MA, Thiers V, Grignon Y, Zignego AL, Brechot C.

Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice.

Hepatology. 1998 Jul;28(1):211-8.

265: Pol S, Fontaine H, Carnot F, Zylberberg H, Berthelot P, Brechot C, Nalpas B.

Predictive factors for development of cirrhosis in parenterally acquired chronic hepatitis C: a comparison between immunocompetent and immunocompromised patients.

J Hepatol. 1998 Jul;29(1):12-9.

264: Pol S, Lamorthe B, Thi NT, Thiers V, Carnot F, Zylberberg H, Berthelot P, Brechot C, Nalpas B.

Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users.

J Hepatol. 1998 Jun;28(6):945-50.

263: Nalpas B, Pol S, Thepot V, Zylberberg H, Berthelot P, Brechot C.

ESBRA 1997 Award lecture: relationship between excessive alcohol drinking and viral infections.

Alcohol Alcohol. 1998 May-Jun;33(3):202-6. Review.

262: Zylberberg H, Chaix ML, Rabian C, Rouzioux C, Aulong B, Brechot C, Viard JP, Pol S.

Tritherapy for human immunodeficiency virus infection does not modify replication of hepatitis C virus in coinfected subjects.

Clin Infect Dis. 1998 May;26(5):1104-6.

261: Sirma H, Weil R, Rosmorduc O, Urban S, Israel A, Kremsdorf D, Brechot C.

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome.

Oncogene. 1998 Apr 23;16(16):2051-63.

260: Pol S, Couillin I, Michel ML, Driss F, Nalpas B, Carnot F, Berthelot P, Brechot C.

Immunotherapy of chronic hepatitis B by anti HBV vaccine.

Acta Gastroenterol Belg. 1998 Apr-Jun;61(2):228-33.

259: Zylberberg H, Nalpas B, Brechot C, Berthelot P.

Significance of repeatedly normal aminotransferase activities in hepatitis C virus-infected patients.

Hepatology. 1998 Apr;27(4):1169.

258: Semprini AE, Persico T, Thiers V, Oneta M, Tuveri R, Serafini P, Boschini A, Giuntelli S, Pardi G, Brechot C.

Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men.

257: Lunel F, Stuyver L, Brechot C, Maertens G.

[Update on hepatitis C virus: its variability and the implications]

Transfus Clin Biol. 1998 Apr;5(2):147-65. Review. French.

256: Berasain C, Patil D, Perara E, Huang SM, Mouly H, Brechot C.

Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon hepatitis B virus genome insertion.

Oncogene. 1998 Mar 12;16(10):1277-88.

255: Thiers V, Pol S, Persico T, Carnot F, Zylberberg H, Berthelot P, Brechot C, Nalpas B.

Hepatitis G virus infection in hepatitis C virus-positive patients co-infected or not with hepatitis B virus and/or human immunodeficiency virus.

J Viral Hepat. 1998 Mar;5(2):123-30.

254: Nicolet J, Loriot MA, Bonte E, Capron F, Franco D, Brechot C.

[Characterization of liver regeneration in the albumin-urokinase transgenic mouse]

Chirurgie. 1998 Feb;123(1):47-53. French.

J Infect Dis. 1998 Apr;177(4):848-54.


253: Paterlini P, Ferrandis E, Mejean A, Emile JF, Tournebize M, Poussin K,

Lellouch A, Groult R, Brechot C, Lacour B.

Evaluation of cell proliferation through a polymerase chain reaction-based cyclin A test.

Anal Biochem. 1997 Nov 1;253(1):140-2.

252: Louha M, Poussin K, Ganne N, Zylberberg H, Nalpas B, Nicolet J, Capron F, Soubrane O, Vons C, Pol S, Beaugrand M, Berthelot P, Franco D, Trinchet JC, Brechot C, Paterlini P.

Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer.

Hepatology. 1997 Oct;26(4):998-1005.

251: Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, Pol S, Brechot C.

Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.

Gastroenterology. 1997 Aug;113(2):567-72.

250: Le Guen B, Squadrito G, Nalpas B, Berthelot P, Pol S, Brechot C.

Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C.

Hepatology. 1997 May;25(5):1250-4.

249: Thiers V, Jaffredo F, Tuveri R, Chodan N, Brechot C.

Development of a simple restriction fragment length polymorphism (RFLP) based assay for HCV genotyping and comparative analysis with genotyping and serotyping tests.

J Virol Methods. 1997 Apr;65(1):9-17.

248: Brechot C.

Hepatitis C virus 1b, cirrhosis, and hepatocellular carcinoma.

Hepatology. 1997 Mar;25(3):772-4.

247: Barba G, Harper F, Harada T, Kohara M, Goulinet S, Matsuura Y, Eder G, Schaff Z, Chapman MJ, Miyamura T, Brechot C.

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets.

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1200-5.

246: Brind A, Jiang J, Samuel D, Gigou M, Feray C, Brechot C, Kremsdorf D.

Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection.

J Hepatol. 1997 Feb;26(2):228-35.

245: Brechot C.

[Cell division: fundamental aspects]

Ann Pathol. 1997;17 Suppl 5:58. French.

244: Tuveri R, Rothschild C, Pol S, Reijasse D, Persico T, Gazengel C, Brechot C, Thiers V.

Hepatitis C virus genotypes in French haemophiliacs: kinetics and reappraisal of mixed infections.

J Med Virol. 1997 Jan;51(1):36-41.

243: Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Brechot C, Sobczak-Thepot J.

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene.

Nat Genet. 1997 Jan;15(1):83-6. Erratum in: Nat Genet 1999 Dec;23(4):481.

242: Brechot C.

[Biology of hepatitis C viruses: clinical implications]

Rev Med Interne. 1997;18(11):893-905. Review. French.


241: Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C.

HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells.

Am J Physiol. 1996 Dec;271(6 Pt 1):G993-1002.

240: Brechot C.

Hepatitis C virus: molecular biology and genetic variability.

Dig Dis Sci. 1996 Dec;41(12 Suppl):6S-21S. Review.

239: Strassburg CP, Alex B, Zindy F, Gerken G, Luttig B, Meyer zum Buschenfelde KH, Brechot C, Manns MP.

Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases.

J Hepatol. 1996 Dec;25(6):859-66.

238: Ka MM, Herve P, Leguenno B, Ndiaye MF, Diop TM, Diop B, Dangou JM, Bao O, Brechot C.

[Low prevalence of ant-hepatitis c virus antibodies in hepatocellular carcinoma in Senegal]

Ann Gastroenterol Hepatol (Paris). 1996 Nov-Dec;31(6):329-32. French.

237: Minami M, Poussin K, Kew M, Okanoue T, Brechot C, Paterlini P.

Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers.

Gastroenterology. 1996 Sep;111(3):691-700.

236: Arbuthnot PB, Bralet MP, Le Jossic C, Dedieu JF, Perricaudet M, Brechot C, Ferry N.

In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector.

Hum Gene Ther. 1996 Aug 20;7(13):1503-14.

235: Fornairon S, Pol S, Legendre C, Carnot F, Mamzer-Bruneel MF, Brechot C, Kreis H.

The long-term virologic and pathologic impact of renal transplantation on chronic hepatitis B virus infection.

Transplantation. 1996 Jul 27;62(2):297-9.

234: Brechot C.

Hepatitis B and C viruses and primary liver cancer.

Baillieres Clin Gastroenterol. 1996 Jul;10(2):335-73. Review.

233: D’Errico A, Fiorentino M, Ponzetto A, Daikuhara Y, Tsubouchi H, Brechot C, Scoazec JY, Grigioni WF.

Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: its specific receptor c-met does.

Hepatology. 1996 Jul;24(1):60-4.

232: Pol S, Cavalcanti R, Carnot F, Legendre C, Driss F, Chaix ML, Thervet E, Chkoff N, Brechot C, Berthelot P, Kreis H.

Azathioprine hepatitis in kidney transplant recipients. A predisposing role of chronic viral hepatitis.

Transplantation. 1996 Jun 27;61(12):1774-6.

231: Brechot C.

[Hepatitis C virus. Structure and genetic variability]

Bull Acad Natl Med. 1996 Jun-Jul;180(6):1219-39; discussion 1239-40. Review. French.

230: Brechot C, Nalpas B, Feitelson MA.

Interactions between alcohol and hepatitis viruses in the liver.

Clin Lab Med. 1996 Jun;16(2):273-87. Review.

229: Kremsdorf D, Garreau F, Capel F, Petit MA, Brechot C.

In vivo selection of a hepatitis B virus mutant with abnormal viral protein expression.

J Gen Virol. 1996 May;77 ( Pt 5):929-39.

228: Bralet MP, Calise D, Brechot C, Ferry N.

In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer.

Lab Invest. 1996 May;74(5):871-81.

227: Desdouets C, Ory C, Matesic G, Soussi T, Brechot C, Sobczak-Thepot J.

ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoter.

FEBS Lett. 1996 Apr 29;385(1-2):34-8.

226: Pawlotsky JM, Lunel F, Zarski JP, Laurent-Puig P, Brechot C.

[Biological diagnosis of hepatitis C virus infection. Role of serological and molecular tests]

Gastroenterol Clin Biol. 1996 Mar;20(2):146-61. Review. French.

225: Zylberberg H, Jiang J, Pialoux G, Driss F, Carnot F, Dubois F, Brechot C, Berthelot P, Pol S.

Alpha-interferon for chronic active hepatitis B in human immunodeficiency virus-infected patients.

Gastroenterol Clin Biol. 1996;20(11):968-71.

224: Pol S, Thiers V, Carnot F, Zins B, Romeo R, Berthelot P, Brechot C.

Effectiveness and tolerance of interferon-alpha 2b in the treatment of chronic hepatitis C in haemodialysis patients.

Nephrol Dial Transplant. 1996;11 Suppl 4:58-61.


223: Arbuthnot P, Bralet MP, Thomassin H, Danan JL, Brechot C, Ferry N.

Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor II regulatory sequences.

Hepatology. 1995 Dec;22(6):1788-96.

222: Desdouets C, Fabre M, Gauthier F, Brechot C, Sobczak-Thepot J.

Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse.

J Hepatol. 1995 Nov;23(5):569-77.

221: Moldvay J, Deny P, Pol S, Brechot C, Lamas E.

[In situ hybridization for the detection of hepatitis C virus RNA in mononuclear cells of peripheral blood from infected patients]

Orv Hetil. 1995 Oct 15;136(42):2267-71. Hungarian.

220: Nalpas B, Feitelson M, Brechot C, Rubin E.

Alcohol, hepatotropic viruses, and hepatocellular carcinoma.

Alcohol Clin Exp Res. 1995 Oct;19(5):1089-95. Review.

219: Minami M, Poussin K, Brechot C, Paterlini P.

A novel PCR technique using Alu-specific primers to identify unknown flanking sequences from the human genome.

Genomics. 1995 Sep 20;29(2):403-8.

218: Giannini C, Thiers V, Nousbaum JB, Stuyver L, Maertens G, Brechot C.

Comparative analysis of two assays for genotyping hepatitis C virus based on genotype-specific primers or probes.

J Hepatol. 1995 Sep;23(3):246-53.

217: Nalpas B, Romeo R, Pol S, Thiers V, Carnot F, Berthelot P, Brechot C.

Serum hepatitis C virus (HCV) RNA: a reliable tool for evaluating HCV-related liver disease in anti-HCV-positive blood donors with persistently normal alanine aminotransferase values.

Transfusion. 1995 Sep;35(9):75

216: Ganne-Carrie N, Kremsdorf D, Garreau F, Thevenin M, Petit MA, Nalpas B, Brechot C.

Effects of ethanol on hepatitis B virus Pre-S/S gene expression in the human hepatocellular carcinoma derived HEP G2 hepatitis B DNA positive cell line.

J Hepatol. 1995 Aug;23(2):153-9.

215: Rosmorduc O, Petit MA, Pol S, Capel F, Bortolotti F, Berthelot P, Brechot C, Kremsdorf D.

In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA.

Hepatology. 1995 Jul;22(1):10-9.

214: Paterlini P, Flejou JF, De Mitri MS, Pisi E, Franco D, Brechot C.

Structure and expression of the cyclin A gene in human primary liver cancer. Correlation with flow cytometric parameters.

J Hepatol. 1995 Jul;23(1):47-52.

213: Delmer A, Tang R, Senamaud-Beaufort C, Paterlini P, Brechot C, Zittoun R.

Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias.

Leukemia. 1995 Jul;9(7):1240-5.

212: Desdouets C, Matesic G, Molina CA, Foulkes NS, Sassone-Corsi P, Brechot C, Sobczak-Thepot J.

Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM.

Mol Cell Biol. 1995 Jun;15(6):3301-9.

211: Pol S, Thiers V, Carnot F, Zins B, Romeo R, Berthelot P, Brechot C.

Efficacy and tolerance of alpha-2b interferon therapy on HCV infection of hemodialyzed patients.

Kidney Int. 1995 May;47(5):1412-8.

210: Rosenberg AR, Zindy F, Le Deist F, Mouly H, Metezeau P, Brechot C, Lamas E.

Overexpression of human cyclin A advances entry into S phase. Oncogene. 1995 Apr 20;10(8):1501-9.

209: Feray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, Reynes M, Okamoto H, Bismuth H, Brechot C.

Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation.

Gastroenterology. 1995 Apr;108(4):1088-96.

208: Phaneuf D, Hadchouel M, Tanguay RM, Brechot C, Ferry N.

Correction of fumarylacetoacetate hydrolase deficiency (type I tyrosinemia) in cultured human fibroblasts by retroviral-mediated gene transfer.

Biochem Biophys Res Commun. 1995 Mar 28;208(3):957-63.

207: Nalpas B, Pol S, Thepot V, Berthelot P, Brechot C.

Hepatocellular carcinoma in alcoholics.

Alcohol. 1995 Mar-Apr;12(2):117-20. Review. No abstract available.

206: Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C.

Hepatitis C virus type 1b (II) infection in France and Italy. Collaborative Study Group.

Ann Intern Med. 1995 Feb 1;122(3):161-8.

205: Pol S, Thiers V, Nousbaum JB, Legendre C, Berthelot P, Kreis H, Brechot C.

The changing relative prevalence of hepatitis C virus genotypes: evidence in emodialyzed patients and kidney recipients.

Gastroenterology. 1995 Feb;108(2):581-3.

204: Paterlini P, Poussin K, Kew M, Franco D, Brechot C.

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma.

Hepatology. 1995 Feb;21(2):313-21.

203: Romeo R, Pol S, Demeret C, Thiers V, Kremsdorf D, Cuillerier E, Berthelot P, Brechot C.

Evidence of non-A, non-B, non-C infection in chronic hepatitis by polymerase chain reaction testing for hepatitis B and C viruses.

J Hepatol. 1995 Feb;22(2):125-9.

202: Brechot C.

[Hepatitis B and C viruses and primary liver cancer]

Rev Prat. 1995 Jan 15;45(2):190-6. Review. French.

201: Jiang JJ, Dubois F, Driss F, Carnot F, Thepot V, Pol S, Berthelot P, Brechot C, Nalpas B.

Clinical impact of drug addiction in alcoholics.

Alcohol Alcohol. 1995 Jan;30(1):55-60.

200: Brechot C.

[Cyclins and carcinogenesis]

C R Seances Soc Biol Fil. 1995;189(1):87-96. French.

199: Didier JM, Mougin C, Paterlini P, Kantelip JP, Brechot C, Lab M.

[Detection of cyclin A mRNA in intra-epithelial lesions of the anogenital tract induced by papillomavirus]

C R Seances Soc Biol Fil. 1995;189(1):111-26. French.

198: Brechot C, Minami M, De Mitri S, Paterlini P.

Hepatitis B and C viruses in hepatitis B surface antigen negative hepatocellular carcinoma patients.

Princess Takamatsu Symp. 1995;25:199-209. Review.

197: Desdouets C, Sobczak-Thepot J, Murphy M, Brechot C.

Cyclin A: function and expression during cell proliferation.

Prog Cell Cycle Res. 1995;1:115-23. Review.

196: Aubin JT, Boulay D, Chapus A, Brechot C, Laure F, Agut H.

Evaluation of a new non-isotopic sandwich hybridization for the detection of HIV1-specific PCR products.

Res Virol. 1995 Jan-Feb;146(1):75-9.


195: Feray C, Gigou M, Samuel D, Paradis V, Wilber J, David MF, Urdea M, Reynes M, Brechot C, Bismuth H.

The course of hepatitis C virus infection after liver transplantation.

Hepatology. 1994 Nov;20(5):1137-43.

194: Poussin K, Harter-Chaput A, Sayada C, Brechot C.

Evaluation of the amplicor HIV1 DNA diagnosis test.

Res Virol. 1994 Nov-Dec;145(6):393-5.

193: Xu LZ, Larzul D, Delaporte E, Brechot C, Kremsdorf D.

Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon).

J Gen Virol. 1994 Sep;75 ( Pt 9):2393-8.

192: Verdon R, Pol S, Landais P, Mattlinger B, Carnot F, Brechot C, Busson M, Kreis H.

Absence of association between HLA antigens and chronicity of viral hepatitis in haemodialyzed patients.

J Hepatol. 1994 Sep;21(3):388-93.

191: Deny P, Fattovich G, Le Gal F, Giustina G, Lecot C, Morsica G, Poinsot H, Alberti A, Brechot C.

Polymerase-chain-reaction-based semi-quantification of hepatitis D viraemia in patients treated with high doses of alpha 2b interferon.

Res Virol. 1994 Sep-Oct;145(5):287-95.

190: Romeo R, Pol S, Berthelot P, Brechot C.

Eradication of hepatitis C virus RNA after alpha-interferon therapy.

Ann Intern Med. 1994 Aug 15;121(4):276-7.

189: Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, Vernier P, Brechot C.

Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.

Eur J Biochem. 1994 Aug 15;224(1):29-38.

188: Brechot C.

Hepatitis C virus genetic variability: clinical implications.

Am J Gastroenterol. 1994 Aug;89(8 Suppl):S41-7. Review.

187: Calmus Y, Marcellin P, Beaurain G, Chatenoud L, Brechot C.

Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen-positive and negative patients.

Eur J Clin Invest. 1994 Aug;24(8):548-52.

186: Pol S, Driss F, Michel ML, Nalpas B, Berthelot P, Brechot C.

Specific vaccine therapy in chronic hepatitis B infection.

Lancet. 1994 Jul 30;344(8918):342. No abstract available.

185: Henglein B, Chenivesse X, Wang J, Eick D, Brechot C.

Structure and cell cycle-regulated transcription of the human cyclin A gene.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5490-4.

184: Bralet MP, Branchereau S, Brechot C, Ferry N.

Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in normal liver.

Am J Pathol. 1994 May;144(5):896-905.

183: Christa L, Simon MT, Flinois JP, Gebhardt R, Brechot C, Lasserre C.

Overexpression of glutamine synthetase in human primary liver cancer.

Gastroenterology. 1994 May;106(5):1312-20.

182: Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, Brouwer JT, Chan SW, Chayama K, Chen DS, et al.

A proposed system for the nomenclature of hepatitis C viral genotypes.

Hepatology. 1994 May;19(5):1321-4. No abstract available.

181: Ackerman Z, Wands JR, Gazitt Y, Brechot C, Kew MC, Shouval D.

Enhancement of HBsAg detection in serum of patients with chronic liver disease following removal of circulating immune complexes.

J Hepatol. 1994 Mar;20(3):398-404.

180: D’Errico A, Grigioni WF, Fiorentino M, Baccarini P, Lamas E, De Mitri S, Gozzetti G, Mancini AM, Brechot C.

Expression of insulin-like growth factor II (IGF-II) in human hepatocellular carcinomas: an immunohistochemical study.

Pathol Int. 1994 Feb;44(2):131-7.

179: Christa L, Felin M, Morali O, Simon MT, Lasserre C, Brechot C, Seve AP.

The human HIP gene, overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity.

FEBS Lett. 1994 Jan 3;337(1):114-8.

178: Moldvay J, Deny P, Pol S, Brechot C, Lamas E.

Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization.

Blood. 1994 Jan 1;83(1):269-73.

177: Marcellin P, Samuel D, Areias J, Loriot MA, Arulnaden JL, Gigou M, David MF, Bismuth A, Reynes M, Brechot C, et al.

Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage live disease.

Hepatology. 1994 Jan;19(1):6-12.

176: Pol S, Wesenfelder L, Dubois F, Roingeard P, Carnot F, Driss F, Brechot C, Goudeau A, Berthelot P.

Influence of human immunodeficiency virus infection on hepatitis delta virus superinfection in chronic HBsAg carriers.

J Viral Hepat. 1994;1(2):131-7.

175: Pol S, Saltiel C, Legendre C, Carnot F, Driss F, Berthelot P, Brechot C, Ruet C, Kreis H.

Effectiveness of adenine arabinoside 5′-monophosphate in kidney transplant recipients with chronic active hepatitis B.

Nephrol Dial Transplant. 1994;9(7):820-3.


174: Pol S, Thiers V, Driss F, Devergie A, Berthelot P, Brechot C, Gluckman E.

Lack of evidence for a role of HCV in hepatitis-associated aplastic anaemia.

Br J Haematol. 1993 Dec;85(4):808-10.

173: Pol S, Romeo R, Zins B, Driss F, Lebkiri B, Carnot F, Berthelot P, Brechot C.

Hepatitis C virus RNA in anti-HCV positive hemodialyzed patients: significance and therapeutic implications.

Kidney Int. 1993 Nov;44(5):1097-100.

172: Delaporte E, Thiers V, Dazza MC, Romeo R, Mlika-Cabanne N, Aptel I, Schrijvers D, Brechot C, Larouze B.

High level of hepatitis C endemicity in Gabon, equatorial Africa.

Trans R Soc Trop Med Hyg. 1993 Nov-Dec;87(6):636-7.

171: Fleurette F, Durieux P, Battista RN, Benhamou JP, Degos F, Brechot C, Courouce AM, Janot C, Trepo C.

Assessment of screening tests for transfusion-associated non-A non-B hepatitis.

Int J Technol Assess Health Care. 1993 Fall;9(4):479-89.

170: De Mitri MS, Pisi E, Brechot C, Paterlini P.

Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas: a study based on PCR.

Liver. 1993 Oct;13(5):259-61.

169: Leonard G, Chaput A, Courgnaud V, Sangare A, Denis F, Brechot C.

Characterization of dual HIV-1 and HIV-2 serological profiles by polymerase chain reaction.

AIDS. 1993 Sep;7(9):1185-9.

168: Housset C, Lamas E, Courgnaud V, Boucher O, Girard PM, Marche C, Brechot C.

Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo.

J Hepatol. 1993 Sep;19(2):252-8.

167: Dazza MC, Trebucq A, Gaudebout C, Jarretou A, Le Hesran JY, Josse R, Delaporte E, Brechot C, Larouze B.

Population-based study of serum hepatitis B virus DNA in Gabon.

Trans R Soc Trop Med Hyg. 1993 Sep-Oct;87(5):539-40.

166: Romeo R, Thiers V, Driss F, Berthelot P, Nalpas B, Brechot C.

Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels.

Transfusion. 1993 Aug;33(8):629-33.

165: Pol S, Driss F, Carnot F, Michel ML, Berthelot P, Brechot C.

[Efficacy of immunotherapy with vaccination against hepatitis B virus on virus B multiplication]

C R Acad Sci III. 1993 Jul;316(7):688-91. French.

164: Kremsdorf D, Garreau F, Duclos H, Thiers V, Schellekens H, Petit MA, Brechot C.

Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient.

J Hepatol. 1993 Jun;18(2):244-50.

163: Chenivesse X, Franco D, Brechot C.

MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis.

J Hepatol. 1993 Jun;18(2):168-72.

162: Sobczak-Thepot J, Harper F, Florentin Y, Zindy F, Brechot C, Puvion E.

Localization of cyclin A at the sites of cellular DNA replication.

Exp Cell Res. 1993 May;206(1):43-8.

161: Nalpas B, Thiers V, Pol S, Driss F, Berthelot P, Brechot C.

HCV infection in alcoholics.

Gastroenterol Jpn. 1993 May;28 Suppl 5:88-90.

160: Roudot-Thoraval F, Pawlotsky JM, Thiers V, Deforges L, Girollet PP, Guillot F, Huraux C, Aumont P, Brechot C, Dhumeaux D.

Lack of mother-to-infant transmission of hepatitis C virus in human immunodeficiency virus-seronegative women: a prospective study with hepatitis C virus RNA testing.

Hepatology. 1993 May;17(5):772-7.

159: Feray C, Gigou M, Samuel D, Bernuau J, Bismuth H, Brechot C.

Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France.

J Hepatol. 1993 Apr;18(1):119-22.

158: Thiers V, Lunel F, Valla D, Azar N, Fretz C, Frangeul L, Huraux JM, Opolon P, Brechot C.

Post-transfusional anti-HCV-negative non-A non-B hepatitis (II) serological and polymerase chain reaction analysis for hepatitis C and hepatitis B viruses.

J Hepatol. 1993 Apr;18(1):34-9.

157: Brechot C, Kremsdorf D.

Genetic variation of the hepatitis C virus (HCV) genome: random events or a clinically relevant issue?

J Hepatol. 1993 Mar;17(3):265-8. Review.

156: Deny P, Lecot C, Jeantils V, Ovaguimian L, Krivitzky A, Brechot C.

Polymerase chain reaction-based detection of hepatitis D virus genome in patients infected with human immunodeficiency virus.

J Med Virol. 1993 Mar;39(3):214-8.

155: Barlat I, Fesquet D, Brechot C, Henglein B, Dupuy d’Angeac A, Vie A, Blanchard JM.

Loss of the G1-S control of cyclin A expression during tumoral progression of Chinese hamster lung fibroblasts.

Cell Growth Differ. 1993 Feb;4(2):105-13.

154: Brechot C.

Oncogenic activation of cyclin A.

Curr Opin Genet Dev. 1993 Feb;3(1):11-8. Review.

153: Feray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H, Brechot C.

Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis.

Gastroenterology. 1993 Feb;104(2):549-55.

152: Reynes M, Tricottet V, Samuel D, Sebagh M, Bismuth A, Arulnaden J, Brechot C, Bismuth H.

Allograft biopsies in situ hybridization HBVDNA detection of serum HBs Ag-repositive patients treated with anti-HBV immunoprophylaxis after liver transplantation for HBV cirrhosis.

Transplant Proc. 1993 Feb;25(1 Pt 2):1347-8.

151: Pol S, Saltiel C, Legendre C, Carnot F, Driss F, Berthelot P, Brechot C, Ruet C, Kreis H.

Efficacy of adenine arabinoside 5′-monophosphate in kidney recipients with chronic active hepatitis B: a pilot study.

Transplant Proc. 1993 Feb;25(1 Pt 2):1446-9.

150: Paterlini P, Suberville AM, Zindy F, Melle J, Sonnier M, Marie JP, Dreyfus F, Brechot C.

Cyclin A expression in human hematological malignancies: a new marker of cell proliferation.

Cancer Res. 1993 Jan 15;53(2):235-8.

149: Andry P, Weber-Buisset MJ, Fraitag S, Brechot C, De Prost Y.

[Bullous drug eruption caused by Introna]

Ann Dermatol Venereol. 1993;120(11):843-5. French.

148: Petit MA, Capel F, Gerken G, Dubanchet S, Brechot C, Trepo C.

Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections.

Arch Virol Suppl. 1993;8:179-87.

147: Brechot C.

Polymerase chain reaction for the diagnosis of hepatitis B and C viral hepatitis.

J Hepatol. 1993;17 Suppl 3:S35-41. Review.

146: Paterlini P, Driss F, Nalpas B, Pisi E, Franco D, Berthelot P, Brechot C.

Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: a study of a low-endemic area.

Hepatology. 1993 Jan;17(1):20-9.

145: Brechot C.

Polymerase chain reaction for the diagnosis of viral hepatitis B and C.

Gut. 1993;34(2 Suppl):S39-44. Review.

144: Brechot C.

[Cyclins and carcinogenesis]

Pathol Biol (Paris). 1993 Jan;41(1):17. French.

143: Zignego AL, Samuel D, Gigou M, Feray C, Arulnaden JL, Monti M, Gentilini P, Reynes M, Benhamou JP, Brechot C, et al.

Patterns of hepatitis delta reinfection after liver transplantation and their evolution during a long term follow-up.

Prog Clin Biol Res. 1993;382:409-17.

142: Lecot C, Jeantils V, Ovaguimian L, Krivitzky A, Brechot C, Deny P.

Polymerase chain reaction-based detection of hepatitis D virus RNA in patients infected with human immunodeficiency virus.

Prog Clin Biol Res. 1993;382:329-35.


141: Pol S, Dubois F, Mattlinger B, Carnot F, Legendre C, Brechot C, Berthelot P, Kreis H.

Absence of hepatitis delta virus infection in chronic hemodialysis and kidney transplant patients in france.

Transplantation. 1992 Dec;54(6):1096-7.

140: Brechot C.

[Molecular aspects of primary liver cancer in men. Role of chronic infection by hepatitis B and C viruses]

Pathol Biol (Paris). 1992 Nov;39(9):898-9. French.

139: Lasserre C, Christa L, Simon MT, Vernier P, Brechot C.

A novel gene (HIP) activated in human primary liver cancer.

Cancer Res. 1992 Sep 15;52(18):5089-95.

138: Lamas E, Baccarini P, Housset C, Kremsdorf D, Brechot C.

Detection of hepatitis C virus (HCV) RNA sequences in liver tissue by in situ hybridization.

J Hepatol. 1992 Sep;16(1-2):219-23.

137: Porchon C, Kremsdorf D, Pol S, Lunel-Fabianni F, Driss F, Opolon P, Berthelot P, Brechot C.

Serum hepatitis C virus RNA and hepatitis B virus DNA in non-A, non-B post-transfusional and sporadic chronic hepatitis.

J Hepatol. 1992 Sep;16(1-2):184-9.

136: Brechot C.

[Liver cancer and hepatitis B and C virus]

Rev Prat. 1992 Sep 1;42(13):1621-7. Review. French.

135: Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Brechot C.

Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma.

Oncogene. 1992 Aug;7(8):1653-6.

134: Zignego AL, Macchia D, Monti M, Thiers V, Mazzetti M, Foschi M, Maggi E, Romagnani S, Gentilini P, Brechot C.

Infection of peripheral mononuclear blood cells by hepatitis C virus.

J Hepatol. 1992 Jul;15(3):382-6.

133: Gerken G, Gerlich WH, Brechot C, Thomas HC, Bonino F, de Moura C, Meyer zum Buschenfelde KH.

Biological standards for hepatitis B virus assays.

J Hepatol. 1992 May;15(1-2):251-5. Review.

132: Nalpas B, Pourcel C, Feldmann G, Housset C, Tiollais P, Brechot C, Berthelot P, Farza H.

Chronic alcohol intoxication decreases the serum level of hepatitis B surface antigen in transgenic mice.

J Hepatol. 1992 May;15(1-2):118-24.

131: Pol S, Legendre C, Saltiel C, Carnot F, Brechot C, Berthelot P, Mattlinger B, Kreis H.

Hepatitis C virus in kidney recipients. Epidemiology and impact on renal transplantation.

J Hepatol. 1992 May;15(1-2):202-6.

130: Housset C, Pol S, Carnot F, Dubois F, Nalpas B, Housset B, Berthelot P, Brechot C.

Interactions between human immunodeficiency virus-1, hepatitis delta virus and hepatitis B virus infections in 260 chronic carriers of hepatitis B virus.

Hepatology. 1992 Apr;15(4):578-83.

129: Feray C, Samuel D, Thiers V, Gigou M, Pichon F, Bismuth A, Reynes M, Maisonneuve P, Bismuth H, Brechot C.

Reinfection of liver graft by hepatitis C virus after liver transplantation.

J Clin Invest. 1992 Apr;89(4):1361-5.

128: Novati R, Thiers V, Monforte AD, Maisonneuve P, Principi N, Conti M, Lazzarin A, Brechot C.

Mother-to-child transmission of hepatitis C virus detected by nested polymerase chain reaction.

J Infect Dis. 1992 Apr;165(4):720-3.

127: Christa L, Zarski JP, Nalpas B, Augereau C, Brechot C.

Nested polymerase chain reaction on cellular DNA in plasma: a rapid method to investigate the collagen type I A2 MspI polymorphic restriction site in alcoholic patients.

Hum Genet. 1992 Mar;88(5):537-40.

126: Berk L, Schalm SW, de Man RA, Heytink RA, Berthelot P, Brechot C, Boboc B, Degos F, Marcellin P, Benhamou JP, et al.

Failure of acyclovir to enhance the antiviral effect of alpha lymphoblastoid interferon on HBe-seroconversion in chronic hepatitis B. A multi-centre randomized controlled trial.

J Hepatol. 1992 Mar;14(2-3):305-9.

125: Nalpas B, Thiers V, Pol S, Driss F, Thepot V, Berthelot P, Brechot C.

Hepatitis C viremia and anti-HCV antibodies in alcoholics.

J Hepatol. 1992 Mar;14(2-3):381-4.

124: Bismuth A, Arulnaden JL, Samuel D, David MF, Pichon F, Mathieu D, Farahmand H, Farrokhi P, Feray C, Brechot C, et al.

[Relapse prevention in liver transplant patients treated for liver involvement due to hepatitis B virus]

Rev Fr Transfus Hemobiol. 1992 Mar;35(2):107-23. French.

123: Zindy F, Lamas E, Chenivesse X, Sobczak J, Wang J, Fesquet D, Henglein B, Brechot C.

Cyclin A is required in S phase in normal epithelial cells.

Biochem Biophys Res Commun. 1992 Feb 14;182(3):1144-54.

122: Papiernik M, Brossard Y, Mulliez N, Roume J, Brechot C, Barin F, Goudeau A, Bach JF, Griscelli C, Henrion R, et al.

Thymic abnormalities in fetuses aborted from human immunodeficiency virus type 1 seropositive women.

Pediatrics. 1992 Feb;89(2):297-301.

121: Brechot C.

[Use of polymerase chain reaction (PCR) for the diagnosis of hepatitis C virus infections]

Ann Med Interne (Paris). 1992;143(6):379-80. French.

120: Gerken G, Paterlini P, Kremsdorf D, Petit MA, Manns M, Meyer zum Buschenfelde KH, Brechot C.

Clinical significance of the polymerase chain reaction (PCR) assay in chronic HBV carriers.

Arch Virol Suppl. 1992;4:97-101.

119: Zindy F, Lamas E, Schmidt S, Kirn A, Brechot C.

Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells.

J Hepatol. 1992 Jan;14(1):30-4.

118: Courgnaud V, Laure F, Fultz PN, Montagnier L, Brechot C, Sonigo P.

Genetic differences accounting for evolution and pathogenicity of simian immunodeficiency virus from a sooty mangabey monkey after cross-species transmission to a pig-tailed macaque.

J Virol. 1992 Jan;66(1):414-9.


117: Pol S, Legendre C, Saltiel C, Carnot F, Brechot C, Berthelot P, Mattlinger B, Kreis H.

[Hepatitis C in kidney recipients. Epidemiology and impact on kidney transplantation]

Presse Med. 1991 Nov 27;20(40):2025-7. French.

116: Kremsdorf D, Porchon C, Kim JP, Reyes GR, Brechot C.

Partial nucleotide sequence analysis of a French hepatitis C virus: implications for HCV genetic variability in the E2/NS1 protein.

J Gen Virol. 1991 Oct;72 ( Pt 10):2557-61.

115: Terre S, Petit MA, Brechot C.

Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo.

J Virol. 1991 Oct;65(10):5539-43.

114: Degos F, Maisonneuve P, Thiers V, Noel L, Erlinger S, Brechot C, Benhamou JP.

 Neonatal transmission of HCV from mother with chronic hepatitis.

Lancet. 1991 Sep 21;338(8769):758.

113: Cariani E, Dubois N, Lasserre C, Briand P, Brechot C.

Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice.

J Hepatol. 1991 Sep;13(2):220-6

112: Paterlini P, Brechot C.

The detection of hepatitis B virus (HBV) in HBsAG negative individuals with primary liver cancer.

Dig Dis Sci. 1991 Aug;36(8):1122-9. Review.

111: Gerken G, Kremsdorf D, Capel F, Petit MA, Dauguet C, Manns MP, Meyer zum Buschenfelde KH, Brechot C.

Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection.

Virology. 1991 Aug;183(2):555-65.

110: Tran A, Kremsdorf D, Capel F, Housset C, Dauguet C, Petit MA, Brechot C.

Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection.

J Virol. 1991 Jul;65(7):3566-7

109: Paterlini P, De Mitri MS, Martin C, Munnich A, Brechot C.

A TaqI polymorphism in the human cyclin A gene.

Nucleic Acids Res. 1991 May 11;19(9):2516. No abstract available.

108: Lamas E, Zindy F, Seurin D, Guguen-Guillouzo C, Brechot C.

Expression of insulin-like growth factor II and receptors for insulin-like growth factor II, insulin-like growth factor I and insulin in isolated and cultured rat hepatocytes.

Hepatology. 1991 May;13(5):936-40.

107: Samuel D, Bismuth A, Mathieu D, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H.

Passive immunoprophylaxis after liver transplantation in HBsAg-positive patients.

Lancet. 1991 Apr 6;337(8745):813-5.

106: Dazza MC, Meneses LV, Girard PM, Paterlini P, Villaroel C, Brechot C, Larouze B.

Polymerase chain reaction for detection of hepatitis B virus DNA in HbsAg seronegative patients with hepatocellular carcinoma from Mozambique.

Ann Trop Med Parasitol. 1991 Apr;85(2):277-9.

105: Cariani E, Lasserre C, Kemeny F, Franco D, Brechot C.

Expression of insulin-like growth factor II, alpha-fetoprotein and hepatitis B virus transcripts in human primary liver cancer.

Hepatology. 1991 Apr;13(4):644-9.

104: Courgnaud V, Laure F, Brossard A, Bignozzi C, Goudeau A, Barin F, Brechot C.

Frequent and early in utero HIV-1 infection.

AIDS Res Hum Retroviruses. 1991 Mar;7(3):337-41.

103: Deny P, Zignego AL, Rascalou N, Ponzetto A, Tiollais P, Brechot C.

Nucleotide sequence analysis of three different hepatitis delta virusesisolated from a woodchuck and humans.

J Gen Virol. 1991 Mar;72 ( Pt 3):73

102: Lorca T, Fesquet D, Zindy F, Le Bouffant F, Cerruti M, Brechot C, Devauchelle G, Doree M.

An okadaic acid-sensitive phosphatase negatively controls the cyclin degradation pathway in amphibian eggs.

Mol Cell Biol. 1991 Feb;11(2):1171-5.

101: Samuel D, Bismuth A, Serres C, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H.

HBV infection after liver transplantation in HBsAg positive patients: experience with long-term immunoprophylaxis.

Transplant Proc. 1991 Feb;23(1 Pt 2):1492-4.

100: Vanhems P, Bresson-Hadni S, Vuitton DA, Miguet JP, Gillet M, Lab M, Brechot C.

Long-term survival without immunosuppression in HIV-positive liver-graft recipient.

Lancet. 1991 Jan 12;337(8733):126. No abstract available

99: Nalpas B, Driss F, Pol S, Hamelin B, Housset C, Brechot C, Berthelot P.

Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease.

J Hepatol. 1991 Jan;12(1):70-4.

98: Driss F, Zarski JP, Courouce AM, Eme D, Brechot C, Berthelot P, Tron F, Nalpas B.

[Significance of isolated anti-HBs antibodies in subjects not vaccinated against hepatitis B viruses]

Gastroenterol Clin Biol. 1991;15(6-7):477-80. French.

97: Levrero M, Stemler M, Pasquinelli C, Alberti A, Jean-Jean O, Franco A, Balsano C, Diop D, Brechot C, Melegari M, et al.

Significance of anti-HBx antibodies in hepatitis B virus infection.

Hepatology. 1991 Jan;13(1):143-9.

96: Nalpas B, Driss F, Pol S, Hamelin B, Housset C, Brechot C, Berthelot P.

Hepatitis C infection in alcoholics.

Alcohol Alcohol Suppl. 1991;1:321-2. Review.

95: Brechot C, Kremsdorf D, Paterlini P, Thiers V.

Hepatitis B virus DNA in HBsAg-negative patients. Molecular characterizatio nand clinical implications.

J Hepatol. 1991;13 Suppl 4:S49-55. Review.

94: Terre S, Rosmorduc O, Kremsdorf D, Petit MA, Brechot C.

Reverse transcription and packaging of hepatitis B virus (HBV)-RNA generates in vivo defective serum HBV particles.

J Hepatol. 1991;13 Suppl 4:S42-8.

93: Gerken G, Kremsdorf D, Petit MA, Manns M, Meyer zum Buschenfelde KH, Brechot C.

Hepatitis B defective virus with rearrangements in the preS gene during HBV chronic infection.

J Hepatol. 1991;13 Suppl 4:S93-6.

92: Kremsdorf D, Porchon C, Brechot C.

Hepatitis C virus (HCV)-RNA in non-A, non-B chronic hepatitis in France. Nucleotide sequence of a French HCV isolate.

J Hepatol. 1991;13 Suppl 4:S24-32.

91: Lamas E, Le Bail B, Housset C, Boucher O, Brechot C.

Localization of insulin-like growth factor-II and hepatitis B virus mRNAs and proteins in human hepatocellular carcinomas.

Lab Invest. 1991 Jan;64(1):98-104.


90: Blanquet V, Wang JA, Chenivesse X, Henglein B, Garreau F, Brechot C, Turleau C.

Assignment of a human cyclin A gene to 4q26-q27.

Genomics. 1990 Nov;8(3):595-7. No abstract available.

89: Brechot C.

[”Non-A-non-B” viruses have been identified]

Presse Med. 1990 Oct 20;19(34):1567-8. French.

88: Brechot C.

[Biological diagnosis of non-A, non-B virus infections from parenteral transfusion and/or sporadic cases]

Rev Fr Transfus Hemobiol. 1990 Oct;33(5):325-33. Review. French.

87: Pol S, Driss F, Devergie A, Brechot C, Berthelot P, Gluckman E.

Is hepatitis C virus involved in hepatitis-associated aplastic anemia?

Ann Intern Med. 1990 Sep 15;113(6):435-7.

86: Cariani E, Seurin D, Lasserre C, Franco D, Binoux M, Brechot C.

Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis.

J Hepatol. 1990 Sep;11(2):226-31.

85: Brechot C.

Polymerase chain reaction. A new tool for the study of viral infections in hepatology.

J Hepatol. 1990 Jul;11(1):124-9. Review.

84: Feray C, Zignego AL, Samuel D, Bismuth A, Reynes M, Tiollais P, Bismuth H, Brechot C.

Persistent hepatitis B virus infection of mononuclear blood cells without concomitant liver infection. The liver transplantation model.

Transplantation. 1990 Jun;49(6):1155-8.

83: Dazza MC, Meneses LV, Girard PM, Villaroel C, Brechot C, Larouze B.

Hepatitis C virus antibody and hepatocellular carcinoma.

Lancet. 1990 May 19;335(8699):1216.

82: Pol S, Debure A, Degott C, Carnot F, Legendre C, Brechot C, Kreis H.

Chronic hepatitis in kidney allograft recipients.

Lancet. 1990 Apr 14;335(8694):878-80.

81: Housset C, Boucher O, Girard PM, Leibowitch J, Saimot AG, Brechot C, Marche C.

 Immunohistochemical evidence for human immunodeficiency virus-1 infection of liver Kupffer cells.

Hum Pathol. 1990 Apr;21(4):404-8.

80: Housset C, Lamas E, Brechot C.

Detection of HIV1 RNA and p24 antigen in HIV1-infected human liver.

Res Virol. 1990 Mar-Apr;141(2):153-9.

79: Wang J, Chenivesse X, Henglein B, Brechot C.

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.

Nature. 1990 Feb 8;343(6258):555-7.

78: Zignego AL, Deny P, Feray C, Ponzetto A, Gentilini P, Tiollais P, Brechot C.

Amplification of hepatitis delta virus RNA sequences by polymerase chain reaction: a tool for viral detection and cloning.

Mol Cell Probes. 1990 Feb;4(1):43-51.

77: Laure F, Courgnaud V, Brechot C.

The polymerase chain reaction in the human immunodeficiency virus diagnosis.

Ann Biol Clin (Paris). 1990;48(6):413-5.

76: Brechot C.

[Hepatitis C virus: a discovery of molecular biology]

Gastroenterol Clin Biol. 1990;14(1):54-5. French.


75: Leblond-Francillard M, Augereau C, Nalpas B, Trinchet JC, Hartmann DJ, Berthelot P, Beaugrand M, Brechot C.

Liver collagen mRNA and serum amino-terminal peptide of type III procollagen (PIIINP) levels in patients with alcoholic liver disease.

J Hepatol. 1989 Nov;9(3):351-8.

74: Buetow KH, Murray JC, Israel JL, London WT, Smith M, Kew M, Blanquet V, Brechot C, Redeker A, Govindarajah S.

Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

Proc Natl Acad Sci U S A. 1989 Nov;86(22):8852-6.

73: Pol S, Dubois F, Roingeard P, Zignego L, Housset C, Brechot C, Goudeau A, Berthelot P.

Hepatitis delta virus infection in French male HBsAg-positive homosexuals. Hepatology. 1989 Sep;10(3):342-5.

72: Marcellin P, Ouzan D, Degos F, Brechot C, Metman EH, Degott C, Chevalier M, Berthelot P, Trepo C, Benhamou JP.

Randomized controlled trial of adenine arabinoside 5′-monophosphate in chronic active hepatitis B: comparison of the efficacy in heterosexual and homosexual patients.

Hepatology. 1989 Sep;10(3):328-31.

71: Quibriac M, Petitjean J, Thiers V, Tiollais P, Brechot C, Freymuth F.

Comparison of a non-radioactive hybridization assay for detection of hepatitis B virus DNA with the radioactive method.

Mol Cell Probes. 1989 Sep;3(3):209-12.

70: Tron F, Degos F, Brechot C, Courouce AM, Goudeau A, Marie FN, Adamowicz P, Saliou P, Laplanche A, Benhamou JP, et al.

Randomized dose range study of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and PreS2 sequences.

J Infect Dis. 1989 Aug;160(2):199-204.

69: Zarski JP, Kuhns M, Berck L, Degos F, Schalm SW, Tiollais P, Brechot C.

Comparison of a quantitative standardized HBV-DNA assay and a classical spot hybridization test in chronic active hepatitis B patients undergoing antiviral therapy.

Res Virol. 1989 Jul-Aug;140(4):283-91.

68: Deny P, Debure A, Agut H, Berche P, Degos F, Nicolas JC, Kreis H, Brechot C.

Detection of human cytomegalovirus DNA in liver biopsies from patients with cytomegalovirus-related liver disease.

Res Virol. 1989 Jul-Aug;140(4):361-72.

67: Roudot-Thoraval F, Kouadja F, Wirquin V, Thiers V, Avons P, Brechot C, Dhumeaux D.

[Prevalence of HBs antigen carriers and markers of B virus replication in a population of pregnant women, in France]

Gastroenterol Clin Biol. 1989 Apr;13(4):353-6. French.

66: Brechot C.

Hepatitis B virus in alcoholic liver disease with hepatocellular carcinoma.

Hepatology. 1989 Mar;9(3):514.

65: Reynes M, Zignego L, Samuel D, Fabiani B, Gugenheim J, Tricottet V, Brechot C, Bismuth H.

Graft hepatitis delta virus reinfection after orthotopic liver transplantation in HDV cirrhosis.

Transplant Proc. 1989 Feb;21(1 Pt 2):2424-5.

64: Driss F, Boboc B, Zarski JP, Cals MJ, Pol S, Eme D, Ekindjian OG, Courouce AM, Brechot C, Berthelot P, et al.

An epidemiological and clinical study of transaminase levels and hepatitis B antibodies in 1,100 blood donors.

Vox Sang. 1989;57(1):43-8.


63: Cariani E, Lasserre C, Seurin D, Hamelin B, Kemeny F, Franco D, Czech MP, Ullrich A, Brechot C.

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

Cancer Res. 1988 Dec 1;48(23):6844-9.

62: Blanquet V, Garreau F, Chenivesse X, Brechot C, Turleau C.

Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.

Hum Genet. 1988 Nov;80(3):274-6.

61: Gripon P, Diot C, Theze N, Fourel I, Loreal O, Brechot C, Guguen-Guillouzo C.

Hepatitis B virus infection of adult human hepatocytes cultured in the presence of dimethyl sulfoxide.

J Virol. 1988 Nov;62(11):4136-43.

60: Laure F, Courgnaud V, Rouzioux C, Blanche S, Veber F, Burgard M, Jacomet C, Griscelli C, Brechot C.

Detection of HIV1 DNA in infants and children by means of the polymerase chain reaction.

Lancet. 1988 Sep 3;2(8610):538-41.

59: Pariente EA, Goudeau A, Dubois F, Degott C, Gluckman E, Devergie A, Brechot C, Schenmetzler C, Bernuau J.

Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation.

Dig Dis Sci. 1988 Sep;33(9):1185-91.

58: Larzul D, Guigue F, Sninsky JJ, Mack DH, Brechot C, Guesdon JL.

Detection of hepatitis B virus sequences in serum by using in vitro enzymatic amplification.

J Virol Methods. 1988 Jul;20(3):227-37.

57: Cariani E, Brechot C.

Detection of DNA sequences by Southern blot.

Ric Clin Lab. 1988 Apr-Sep;18(2-3):161-70. Review.

56: Pasquinelli C, Garreau F, Bougueleret L, Cariani E, Grzeschik KH, Thiers V, Croissant O, Hadchouel M, Tiollais P, Brechot C.

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

J Virol. 1988 Feb;62(2):629-32.

55: Brechot C.

[Diagnosis and prevention of hepatitis B virus infections: applied example of genetic recombinations]

Rev Prat. 1988 Jan 14;38(1):35-44. French. No abstract available.

54: Degos F, Lugassy C, Degott C, Debure A, Carnot F, Theirs V, Tiollais P, Kreis H, Brechot C.

Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients. A prospective study of 90 patients.

Gastroenterology. 1988 Jan;94(1):151-6.

53: Hadchouel M, Pasquinelli C, Fournier JG, Hugon RN, Scotto J, Bernard O, Brechot C.

Detection of mononuclear cells expressing hepatitis B virus in peripheral blood from HBsAg positive and negative patients by in situ hybridisation.

J Med Virol. 1988 Jan;24(1):27-32.


52: Pol S, Thiers V, Nalpas B, Degos F, Gazengel C, Carnot F, Tiollais P, Wands JR, Berthelot P, Brechot C.

Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors.

Eur J Clin Invest. 1987 Dec;17(6):515-21.

51: Larzul D, Thiers V, Courouce AM, Brechot C, Guesdon JL.

Non-radioactive hepatitis B virus DNA probe for detection of HBV-DNA in serum.

J Hepatol. 1987 Oct;5(2):199-204.

50: Ouzan D, Degos F, Marcellin P, Linberg J, Chevallier M, Degott C, Brechot C, Chossegros P, Weiss AM, Hirtz J, et al.

[Vidarabine treatment of chronic active hepatitis associated with hepatitis B virus multiplication. A randomized multicenter study]

Gastroenterol Clin Biol. 1987 Aug-Sep;11(8-9):568-73. French.

49: Brechot C.

Hepatitis B virus (HBV) and hepatocellular carcinoma. HBV DNA status and its implications.

J Hepatol. 1987 Apr;4(2):269-79. Review.

48: Laure F, Chatenoud L, Pasquinelli C, Gazengel C, Beaurain G, Torchet MF, Zagury D, Bach JF, Brechot C.

Frequent lymphocytes infection by hepatitis B virus in haemophiliacs.

Br J Haematol. 1987 Feb;65(2):181-5.

47: Laure F, Leonard R, Mbayo K, Lurhuma Z, Kayembe N, Brechot C, Sarin PS, Sarngadharan M, Wong-Staal F, Gallo RC, et al.

Genomic diversity of Zairian HIV isolates: biological characteristics and clinical manifestation of HIV infection.

AIDS Res Hum Retroviruses. 1987;3(4):343-53.


46: Chaussade S, Thiers V, Boboc B, Housset C, Brechot C, Degos F.

[HBe antigen and B virus DNA in patients with chronic active hepatitis]

Gastroenterol Clin Biol. 1986 Nov;10(11):744-7. French.

45: Hadengue A, Thiers V, Santelli D, Bismuth H, Brechot C.

[Presence of DNA sequences of hepatitis B virus in a fibrolamellar carcinoma of the liver]

Gastroenterol Clin Biol. 1986 Oct;10(10):677-80. French.

44: Budkowska A, Riottot MM, Dubreuil P, Lazizi Y, Brechot C, Sobczak E, Petit MA, Pillot J.

Monoclonal antibody recognizing pre-S(2) epitope of hepatitis B virus: characterization of pre-S(2) epitope and anti-pre-S(2) antibody.

J Med Virol. 1986 Oct;20(2):111-25.

43: Wands JR, Fujita YK, Isselbacher KJ, Degott C, Schellekens H, Dazza MC, Thiers V, Tiollais P, Brechot C.

Identification and transmission of hepatitis B virus-related variants.

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6608-12.

42: Thiers V, Bouchardeau F, Courouce AM, Tiollais P, Brechot C.

[Hepatitis B virus DNA as a marker of viral multiplication: comparison with Hbe antigen and anti-HBe antibody]

Presse Med. 1986 Jun 28;15(26):1219-22. French.

41: Berthelot P, Neurath R, Courouce AM, Brechot C, Degos F, Tron F, Girard M

Hepatitis B vaccines with pre-S gene product.

Lancet. 1986 May 17;1(8490):1150.

40: Pol S, Nalpas B, Bezeaud A, Brechot C, Berthelot P.

[Occurrence of increased alpha-fetoprotein in non-neoplastic hepatopathies of alcoholic or non-alcoholic origin]

Gastroenterol Clin Biol. 1986 Feb;10(2):112-6. French.

39: Pasquinelli C, Laure F, Chatenoud L, Beaurin G, Gazengel C, Bismuth H, Degos F, Tiollais P, Bach JF, Brechot C.

Hepatitis B virus DNA in mononuclear blood cells. A frequent event in hepatitis B surface antigen-positive and -negative patients with acute and chronic liver disease.

J Hepatol. 1986;3(1):95-103.

38: Degos F, Duhamel G, Brechot C, Nalpas B, Courouce AM, Tron F, Berthelot P.

Hepatitis B vaccination in chronic alcoholics.

J Hepatol. 1986;2(3):402-9.


37: Saddi RS, Ebelin P, Pouliquen A, Gautreau C, Durand J, Jammet P, Courouce AM, Brechot C, Franco D, Thibult N.

Hepatitis B vaccination and idiopathic haemochromatosis.

Lancet. 1985 Nov 9;2(8463):1061-2.

36: Pontisso P, Chemello L, Fattovich G, Alberti A, Realdi G, Brechot C.

Relationship between HBcAg in serum and liver and HBV replication in patients with HBsAg-positive chronic liver disease.

J Med Virol. 1985 Oct;17(2):145-52.

35: Laure F, Zagury D, Saimot AG, Gallo RC, Hahn BH, Brechot C.

Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex.

Science. 1985 Aug 9;229(4713):561-3.

34: Hadchouel M, Scotto J, Huret JL, Molinie C, Villa E, Degos F, Brechot C.

Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line.

J Med Virol. 1985 May;16(1):61-6.

33: Scotto J, Hadchouel M, Wain-Hobson S, Sonigo P, Courouce AM, Tiollais P, Brechot C.

Hepatitis B virus DNA in Dane particles: evidence for the presence of replicative intermediates.

J Infect Dis. 1985 Apr;151(4):610-7.

32: Wands JR, Isselbacher KJ, Brechot C, Tiollais P.

Monoclonal radioimmunoassays and HBV-DNA hybridisation in hepatocellular carcinoma.

Lancet. 1985 Feb 23;1(8426):455.

31: Brechot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, Bismuth H, Trepo C, Benhamou JP, Wands J, et al.

Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen.

N Engl J Med. 1985 Jan 31;312(5):270-6.

30: Brechot C.

[Application of hepatitis B virus DNA cloning in the diagnosis of infections related to hepatitis B virus]

Ann Biol Clin (Paris). 1985;43(4):351-4. French.

29: Krogsgaard K, Kryger P, Aldershvile J, Andersson P, Brechot C.

Hepatitis B virus DNA in serum from patients with acute hepatitis B.

Hepatology. 1985 Jan-Feb;5(1):10-3.

28: Nalpas B, Berthelot P, Thiers V, Duhamel G, Courouce AM, Tiollais P, Brechot C.

Hepatitis B virus multiplication in the absence of usual serological markers. A study of 146 chronic alcoholics.

J Hepatol. 1985;1(2):89-97.


27: Brechot C.

[Hepatitis B virus: a better knowledge of its structure and variations in the expression of the viral disease]

Gastroenterol Clin Biol. 1984 Aug-Sep;8(8-9):641-5. Review. French.

26: Pontisso P, Poon MC, Tiollais P, Brechot C.

Detection of hepatitis B virus DNA in mononuclear blood cells.

Br Med J (Clin Res Ed). 1984 May 26;288(6430):1563-6.

25: Dejean A, Lugassy C, Zafrani S, Tiollais P, Brechot C.

Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus.

J Gen Virol. 1984 Mar;65 ( Pt 3):651-5.

24: Brechot C, Bernuau J, Thiers V, Dubois F, Goudeau A, Rueff B, Tiollais P, Benhamou JP.

Multiplication of hepatitis B virus in fulminant hepatitis B.

Br Med J (Clin Res Ed). 1984 Jan 28;288(6413):270-1.

23: Gazengel C, Courouce AM, Torchet MF, Kremp O, Brangier J, Brechot C, Degos F

Use of HBV vaccine in hemophiliacs.

Scand J Haematol Suppl. 1984;40:323-8.


22: Degos F, Brechot C, Nalpas B, Duhamel G, Courouce AM, Tron F, Berthelot P.

Hepatitis B vaccination and alcoholic cirrhosis.

Lancet. 1983 Dec 24-31;2(8365-66):1498.

21: Scotto J, Hadchouel M, Hery C, Alvarez F, Yvart J, Tiollais P, Bernard O, Brechot C.

Hepatitis B virus DNA in children’s liver diseases: detection by blot hybridisation in liver and serum.

Gut. 1983 Jul;24(7):618-24.

20: Scotto J, Hadchouel M, Hery C, Yvart J, Tiollais P, Brechot C.

Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers.

Hepatology. 1983 May-Jun;3(3):279-84.

19: Dejean A, Brechot C, Tiollais P, Wain-Hobson S.

Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5.

Proc Natl Acad Sci U S A. 1983 May;80(9):2505-9.

18: Guguen-Guillouzo C, Clement B, Campion JP, Brechot C, Fauchet R, Brissot P, Guillouzo A, Bourel M.

[Excretion of HBs and HBe antigens by normal human adult hepatocytes infected in vitro by hepatitis B virus]

Presse Med. 1983 Apr 30;12(19):1232-3. French.

17: Barin F, Goudeau A, Brechot C, Romet-Lemonne J, Sureau C, Lesage G.

Further studies on production and characterization of HBsAg derived from a human hepatoma cell line (PLC/PRF/5).

Dev Biol Stand. 1983;54:81-92.

16: Brechot C, Dejean A, Tiollais P.

Hepatitis B viral DNA sequences in the infected tissues.

Prog Clin Biol Res. 1983;143:345-56.

15: Brechot C, Wain-Hobson S, Pourcel C, Dejean A, Hadchouel M, Scotto J, Tiollais P.

Hepatitis B virus DNA and human hepatocellular carcinoma.

Prog Clin Biol Res. 1983;132D:495-504.






14: Brechot C.

[What is the role of hepatitis B virus in the appearance of hepatocellular carcinomas in patients with alcoholic cirrhosis?]

Gastroenterol Clin Biol. 1982 Oct;6(10):727-30. French.

13: Dejean A, Vitvitski L, Brechot C, Trepo C, Tiollais P, Charnay P.

Presence and state of woodchuck hepatitis virus DNA in liver and serum of woodchucks: further analogies with human hepatitis B virus.

Virology. 1982 Aug;121(1):195-9.

12: Brechot C, Nalpas B, Courouce AM, Duhamel G, Callard P, Carnot F, Tiollais P, Berthelot P.

Evidence that hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease.

N Engl J Med. 1982 Jun 10;306(23):1384-7.

11: Franco D, Castaing D, Brechot C, Morin J.

[Is aflatoxin B1 a hepatic carcinogen in man?]

Gastroenterol Clin Biol. 1982 Feb;6(2):125-8. French.

10: Dejean A, Carloni G, Brechot C, Tiollais P, Wain-Hobson S.

Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA.

J Cell Biochem. 1982;20(3):293-301.


9: Brechot C, Hadchouel M, Scotto J, Degos F, Charnay P, Trepo C, Tiollais P.

Detection of hepatitis B virus DNA in liver and serum: a direct appraisal of the chronic carrier state.

Lancet. 1981 Oct 10;2(8250):765-8.

8: Brechot C, Hadchouel M, Scotto J, Fonck M, Potet F, Vyas GN, Tiollais P.

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

Proc Natl Acad Sci U S A. 1981 Jun;78(6):3906-10.

7: Wain-Hobson S, Pourcel C, Brechot C, Charnay P, Dubois MF, Fritsch A, Gervais M, Louise A, Tiollais P.

Structure and expression of the hepatitis B virus genome.

Dev Biol Stand. 1981;50:293-300.

6: Brechot C, Tiollais P.

[Genetic engineering and the hepatitis B virus]

Gastroenterol Clin Biol. 1981 Jan;5(1):93-100. Review. French.

5: Brechot C, Pourcel C, Louise A, Rain B, Tiollais P.

Detection of hepatitis B virus DNA sequences in human hepatocellular carcinoma in an integrated form.

Prog Med Virol. 1981;27:99-102.


4: Brechot C, Trepo C, Ninova-Bradistilova D, Goudeau A, Degott C, Maupas P, Potet F, Benhamou JP.

Hepatitis B core antigen in hepatocytes of patients with chronic active hepatitis.

Dig Dis Sci. 1980 Aug;25(8):593-6.

3: Brechot C, Pourcel C, Louise A, Rain B, Tiollais P.

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma.

Nature. 1980 Jul 31;286(5772):533-5.

2: Brechot C, Hecht Y, Ferrier JP.

[Endotoxins of Gram-negative bacteria in liver diseases]

Gastroenterol Clin Biol. 1980 Apr;4(4):289-305. Review. French.



1: Tobelem G, Michel H, de la Baume H, Brechot C, Degos L, Schaison G.

[Thrombocytopenic purpura during heparinotherapy. Two cases (author’s transl)]

Nouv Presse Med. 1979 Nov 12;8(44):3649-52. French.